31/08/2025 - AstraZeneca plc: Presentation (ESC2025 Presentation 20250831)

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Meet AZN Management: ESC 2025

Conference call and webcast for investors and analysts

31 August 2025



Meet AZN Management @ ESC - agenda

Furthering the AstraZeneca ambition Ruud Dobber, EVP, BioPharmaceuticals Business

Addressing unmet need in

cardiometabolic diseases

Sharon Barr, EVP, BioPharmaceuticals R&D

baxdrostat - Phase III BaxHTN:

baxdrostat in hard-to-control hypertension

Dr Bryan Williams, Chair of Medicine, University College London

Delivering next-wave of CVRM

growth with baxdrostat

Sharon Barr, EVP, BioPharmaceuticals R&D

Ruud Dobber, EVP, BioPharmaceuticals Business

Closing remarks and Q&A session

3



Furthering

the AstraZeneca ambition

Ruud Dobber

EVP, BIOPHARMACEUTICALS BUSINESS



Ambition - $80bn Total Revenue by 2030 & sustained

2030+ growth

Working on "today, tomorrow and the day after"

Illustrative only, not to scale

Launching key NMEs

$80bn

Beyond 2030

ADCs and Radioconjugates

Cell therapy and T-cell engagers Gene therapy

Existing portfolio

AZD0120

camizestrant rilvegostomig surovatamig

saruparib volrustomig AZN ADCs

Next-generation IO bispecifics

Weight management and risk factors

Calquence Datroway Enhertu

Imfinzi/Imjudo Tagrisso Truqap

AZD5004

baxdrostat dapa FDCs

laroprovstat tozorakimab

$54.1bn

Airsupra

Saphnelo

hMPV/RSV vaccine

IRA impact

Loss of Exclusivity

Breztri

Fasenra

Lokelma

Ultomiris

Tezspire

Wainua

efzimfotase alfa

gefurulimab

eneboparatide

Brilinta Farxiga

Lynparza

Soliris

2024

2030 Total Revenue ambition not dependent upon future M&A

2030

5 Note: Ambition to achieve $80bn in Total Revenue by 2030 is risk-adjusted, based on long-range plan as of AstraZeneca Investor Day May 2024. Medicines and assets listed reflect key contributors to 2030 Total Revenue ambition; however, this list is not exhaustive. Medicines and assets listed in alphabetical order and sorted by therapy area. Laroprovstat previously AZD0780. Collaboration partners: Daiichi Sankyo (Enhertu, Datroway), Amgen (Tezspire),

Ionis (Wainua), Compugen (rilvegostomig), Merck & Co., Inc. (Lynparza).

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Disclaimer

AstraZeneca plc published this content on August 31, 2025, and is solely responsible for the information contained herein. Distributed via Public Technologies (PUBT), unedited and unaltered, on August 31, 2025 at 20:04 UTC.

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